Health & biology · November 2025

One-shot CRISPR lowers cholesterol

A single infusion edits a liver gene and halves LDL cholesterol.

In a 15-patient phase 1 trial, CRISPR Therapeutics' CTX310 used lipid nanoparticles to switch off ANGPTL3 in the liver, lowering LDL cholesterol by about 50% and triglycerides by about 55%. In-body gene editing moved toward common diseases.

See it in the living tree Wikipedia Source

Arcs above join it to what it stood on, arcs below to what it led to. The bar places this stretch on the tree's whole timeline.

What it built on 2

mRNA vaccines 2020
CRISPR gene editing 2012

Related measurements

The dashed line marks when it first worked.

Cost to sequence a human genome Latest: 525 $ (2022) Source: Our World in Data

Life expectancy at birth Latest: 73.2 years (2023) Source: Our World in Data