Health & biology · January 2026

AlphaGenome

One model predicts how any DNA change alters gene regulation.

Google DeepMind's AlphaGenome, published in Nature, reads up to a million DNA letters and predicts 5,930 human genomic signals including gene expression and splicing. It gave the non-coding 98% of the genome a usable variant-effect model.

See it in the living tree Wikipedia Source

Arcs above join it to what it stood on, arcs below to what it led to. The bar places this stretch on the tree's whole timeline.

What it built on 3

AlphaFold 3 2024
Transformer 2017
Human Genome Project 2003

Watch

AlphaGenome Atlas: Understanding the human genomeGoogle DeepMind · YouTube

Related measurements

The dashed line marks when it first worked.

Cost to sequence a human genome Latest: 525 $ (2022) Source: Our World in Data

Training compute of notable AI models Source: Epoch AI, Notable AI Models (CC BY 4.0)